[4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester
[4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester
CAS: 879486-21-2
Molecular Formula: C18H28BN3O3
[4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester - Names and Identifiers
| Name | [4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester |
| Synonyms | N-(4-methylpiperazin-1-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide [3-(1'-AMINO-4'-METHYLPIPERAZINE-1-CARBONYL)PHENYL] BORONIC ACID PINACOL ESTER [4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester n-(4-Methylpiperazin-1-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide Benzamide, N-(4-methyl-1-piperazinyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- |
| CAS | 879486-21-2 |
[4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester - Physico-chemical Properties
| Molecular Formula | C18H28BN3O3 |
| Molar Mass | 345.24 |
| Density | 1.14±0.1 g/cm3(Predicted) |
| pKa | 12.25±0.20(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD26142763 |
[4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester - Introduction
[4-(1'-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester, also known as [4-(1 '-Amino-4'-methylpiperazine-1-carbonyl)-phenyl] boronic acid pinacol ester.
Nature:
-Appearance: White or off-white crystalline solid
-Molecular formula: C20H30BClN4O2
-Molecular weight: 396.84g/mol
Use:
-As an intermediate in organic synthesis: The compound can be used to prepare some drugs and chemical reagents, such as anti-cancer drugs, biologically active molecules and ligands.
-For drug development: It can be used as a precursor compound for drug development and participate in drug design, synthesis and activity evaluation.
-Organometallic chemistry research: As an organoboron donor, this compound can be used in organometallic catalyzed reactions, such as Suzuki coupling reactions.
Preparation Method:
The preparation method of this compound is more complicated, and the basic steps are as follows:
1.4-methyl piperazine and hydroquinone amide are reacted in chloroform (CHCl3) to generate precursor compounds.
2. The precursor compound is reacted with boric acid and tin (II) as a catalyst in the Pinacol pinacolone ether to obtain the final product.
Safety Information:
The compound can be relatively safe under correct operation, but the following aspects still need to be paid attention:
-the eye, skin and mucous membrane irritation, contact should be avoided.
-May affect the respiratory system and digestive system, and appropriate protective measures should be taken.
-During use, good ventilation conditions should be ensured.
-Chemical waste must be disposed of properly and in a compliant environment.
Nature:
-Appearance: White or off-white crystalline solid
-Molecular formula: C20H30BClN4O2
-Molecular weight: 396.84g/mol
Use:
-As an intermediate in organic synthesis: The compound can be used to prepare some drugs and chemical reagents, such as anti-cancer drugs, biologically active molecules and ligands.
-For drug development: It can be used as a precursor compound for drug development and participate in drug design, synthesis and activity evaluation.
-Organometallic chemistry research: As an organoboron donor, this compound can be used in organometallic catalyzed reactions, such as Suzuki coupling reactions.
Preparation Method:
The preparation method of this compound is more complicated, and the basic steps are as follows:
1.4-methyl piperazine and hydroquinone amide are reacted in chloroform (CHCl3) to generate precursor compounds.
2. The precursor compound is reacted with boric acid and tin (II) as a catalyst in the Pinacol pinacolone ether to obtain the final product.
Safety Information:
The compound can be relatively safe under correct operation, but the following aspects still need to be paid attention:
-the eye, skin and mucous membrane irritation, contact should be avoided.
-May affect the respiratory system and digestive system, and appropriate protective measures should be taken.
-During use, good ventilation conditions should be ensured.
-Chemical waste must be disposed of properly and in a compliant environment.
Last Update：2024-04-09 02:00:56
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